Immediately after a cut or crush PNI, the distal (away from the body’s center) portion of the body being innervated by that nerve is rendered without function and sensation. More importantly, the distal portion of a cut or crushed peripheral nerve always undergoes programmed degeneration. Recovery after degeneration is exclusively mediated by regeneration of the proximal (upper) portion on the nerve. Unfortunately regrowth of the proximal axons is very slow (~1mm/day) and highly imperfect. The timeline to maximal recovery is measured in several months to as many as three (3) years. And maximum recovery ranges from 0-75% of the preinjury sensation of function as measured at the fingertips or toes.
Most importantly of all, there is no method or technology available today to treat PNI that improves upon the speed or the quality of the natural regeneration process. Neuraptive is developing the AxoFuse Nerve Repair Kit™ (AxoFuse®) to fill this gap in the treatment of severed peripheral nerves leading to significant improvement in clinical outcomes.